Figure 6.

Murine autoimmune disease model genes center around the autoreactive B cell peripheral tolerance network in the middle of combined human autoimmune disease polygenic risk networks. Light blue diamond – Monogenic human SLE gene; dark blue hexagon – Polygenic human SLE gene; dark green triangle – murine lupus gene; light green rounded rectangle – murine peripheral B cell tolerance gene; light red rectangle – murine central B cell tolerance gene; dark red inverted triangle – murine autoimmune type 1 diabetes gene; light orange parallelogram– human monogenic autoimmune type 1 diabetes gene; dark orange octagon– human polygenic autoimmune type 1 diabetes gene; yellow circles – Overlapping genes. Downloadable/Interactive network diagram can be found at: https://doi.org/10.18119/N9MW3G.