Table 2.

Disease Network Overlap.

	Disease	Exp. Overlapsa	Fold O-Rb	Pc
Human Polygenic: Monogenic Overlap	SLE	0.35	26	6.8E-11
	T1D	0.03	35	2.8E-02
Combined Human: Murine Overlap	SLE	0.82	16	1.6E-12
	T1D	0.08	63	1.2E-08

Overlap of disease networks supporting Figures 1, 2 (Human Polygenic: Monogenic Overlap) and Figures 4, 5 (Combined Human: Murine Overlap). ^aExp. Overlaps indicate the number of expected overlapping nodes. Assuming similar length lists were randomly selected from the genome (unassociated). ^bFold O-R indicates the fold over-representation compared to expectation. ^cP indicates p-value for hypergeometric distribution assuming independence of the two networks.