Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 24;13:956369. doi: 10.3389/fimmu.2022.956369

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhang, Li, Xu, Xu, Lyu, Liu, Li, Zhang, Sun, Ma, Qiao and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Study design. (A) Ninety-five participants were recruited and received two doses of CoronaVac vaccines. Blood samples were collected at four time points before and after vaccine injection. (B) Serum separation. (C) MALDI-TOF MS and immunogenicity analysis on all the collected serum samples. (D) MALDI-TOF MS data processing using MALDIquant and Metaboanalyst. (E) Feature selection based on volcano plot and variable importance in projection (VIP) scores by PLS-DA. Hierarchical cluster analyses (HCA) showed the intensity distribution of the selected features among samples. Peaks with an asterisk are peaks of higher intensity filtered by the signal-to-noise ratio and are included in the analysis. Peaks without an asterisk are by default noise peaks and are not included in the analysis.