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. 2022 Sep 7;22:1131. doi: 10.1186/s12913-022-08158-0

Table 21.

Description of Studies: mixed conditions

Authors, Year Condition CEA CUA Setting N (participants) Baseline Characteristics Intervention/ comparator(s) effectiveness measure(s); cost measures (price year) Perspective Time horizon
Larsen et al. 2016 [65*] Dermatology Norway; N Participants: 169

telephone-based individualised motivational interviewing, as a follow-up to a 3-week climate therapy/heliotherapy (CHT) programme, compared to TAU following the CHT.

Intervention: 86

Control: 83

15D instrument of health-related quality of life; Healthcare and employment 6mths
Age in years (mean, SD): Intervention: 46.2 (12.7); Control: 46.5 (13.0) Euros (2012)
Sex (% female): Intervention: 40.7 Control: 47
Ethnicity (% white): Not given
Maes et al. 2014 [73*] Tinnitus Netherlands; N Participants: 492

stepped care, including an individual consultation with a psychologist then a programme comprising key elements of CBT for those with moderate or severe tinnitus compared to standard stepped care treatment.

Intervention: 245

Control: 247

Health Utilities Index Mark III (HUI) Healthcare and societal 12mths
Patients referred to an audiology centre Age in years (mean, SD): 54.21 (11.52) Converted to US$ (from Euros) (2009)
Sex (% female): 37.2
Ethnicity (% white): Not given
Parry et al. 2012 [85*] Asthma England; N Participants: 94

Individual CBT (introductory session followed by 4-6 weekly or fortnightly 1 hr. sessions, with two follow up sessions if considered necessary, compared to usual care.

Intervention: 50

Control: 44

Panic-fear sub-scale of the Asthma Symptom Checklist, EQ-5D-3L; Healthcare 6 mths
Sheffield Age in years (mean, range): Intervention: 47.0 (28-65) Control: 43.8 (25-61) £ (year not given)
Sex (% female): Intervention: 60.7 Control group: 64.5
Ethnicity (% white): Not given
Rolving et al. 2016 [89*] Surgery Denmark; N Participants: 90

group-based CBT, six 3-hour sessions, four prior and two post-surgery (at 3 and 6mths), delivered by a multidisciplinary team, compared to usual care.

Intervention: 59

Control: 31

EQ-5D scores (Danish tariff); Societal 12mths
Hospital Age in years (mean, range): mean age 50.1 (28-64), Euros (2014)
Sex (% female): 57
Ethnicity (% white): Not given
Tyrer et al. 2014 [94*] Secondary care England; N Participants: Control: 444

CBT for health anxiety (CBT-HA), 5-10 sessions with additional booster sessions allowed, compared to standard care.

Intervention: 219

Control: 225

HAI, EQ-5D; Health and social care 24 months
Hospitals (multi-centre) Age in years (mean, SD): Intervention: 50·3 (13·6); Control: 47·0 (13·4) £ (2008-09 financial year)
Sex (% female): Intervention: 52%; Control: 55
Ethnicity (% white): Intervention: 80; Control: 76
van der Aa et al. 2017 [96*] Vision impairment Netherlands and Belgium; N Participants: 265

Stepped care (step 1 watchful waiting, 2 guided self-help course based on CBT, 3 problem solving treatment, 4 referral to GP) compared to usual care.

Intervention: 131

Control: 134

HADS-A, CES-D, EQ-5D-3L (Dutch tariff); Healthcare and societal 24mths
Outpatient clinics Age in years (mean, SD): Intervention: 72.4 (12.5); Control: 74.9 (11.9) Euros (2013)
Sex (% female): Intervention: 69%; Control: 70
Ethnicity (% white): Not given