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. 2022 Jun 30;71(9):2020–2033. doi: 10.2337/db21-0958

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© 2022 by the American Diabetes Association

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Biomechanical phenotyping of mouse aortas. (A) Systolic and diastolic blood pressure of animals 8 weeks after STZ injection. (B) Change in diameters of carotid arteries during vessel active testing. KCl induces Ca²⁺ dependent membrane depolarization; PE induces EC-independent vessel contraction; acetylcholine (Ach) induces EC-dependent relaxation; l-NAME blocks NO synthase to induce EC-dependent contraction; the NO donor sodium nitroprusside (SNP) induces EC-independent relaxation. (C) Passive mechanics of carotid arteries (calculated at 120 mmHg). WT control, n = 5 mice; WT T1D, n = 4; integrin α5/2 control, n = 6; and T1D integrin α5/2, n = 5. Analysis was by two-way ANOVA. Ctrl, control.