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Murine pharmacokinetics for MBX-4055. (A) Mean ± S.D. MBX-4055 vs. MBX-2366 plasma concentrations in mice after single dose administration (n = 3 per timepoint). MBX-4055 at 30 mg/kg PO (red circles) or 10 mg/kg IV (orange triangles); MBX-2366 at 30 mg/kg PO (black circles). (B) Calculated pharmacokinetic parameters.
