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. 2022 Mar 24;18(8):1982–2000. doi: 10.1080/15548627.2022.2050663

Figure 1.

Figure 1.

Schema of the VMA21 protein and details of novel follicular lymphoma (FL)-associated VMA21 mutations. (A) Schema of the VMA21 protein comprising 101 amino acids and novel mutations detected in FL. The VMA21 protein is recurrently targeted by a nonsense mutation (p.93X) resulting in a shortened protein of 92 amino acids. Blue: transmembrane domains. (B) Sanger sequence tracings. T = lymphoma B cells, N = paired CD3+ T cells. (C) Schema of the chaperone function of WT VMA21 toward V-ATPase assembly in the ER/Golgi.