Table 1.
Characteristics of stage I/II endometrial cancer patients with isolated tumor cells, overall and by adjuvant treatment. NAT/VBT no adjuvant therapy/vaginal brachytherapy; LND lymph node dissection
| Overall N=175 | NAT/VBT N=76 | External beam radiation N=21 | Chemotherapy +/− radiation N=78 | p | |
|---|---|---|---|---|---|
| Age (median, range) | 63 (31 – 91) | 62 (34 – 91) | 65 (51 – 83) | 63 (31 – 78) | 0.64 |
|
| |||||
| # positive SLN | 1 (1 – 6) | 1 (1 – 4) | 1 (1 – 5) | 1 (1 – 6) | 0.009 |
|
| |||||
| # negative LN | 6 (0 – 50) | 7 (0 – 50) | 12 (1 – 37) | 5 (0 – 39) | 0.38 |
|
| |||||
| Grade | 0.05 | ||||
| 1 | 100 (57.1) | 52 (68.4) | 11 (52.4) | 37 (47.4) | |
| 2 | 55 (31.4) | 20 (26.3) | 8 (38.1) | 27 (34.6) | |
| 3 | 20 (11.4) | 4 (5.3) | 2 (9.5) | 14 (18.0) | |
|
| |||||
| LVSI | 0.003 | ||||
| No | 56 (32.0) | 36 (47.4) | 6 (28.6) | 14 (18.0) | |
| Yes | 118 (67.8) | 40 (52.6) | 15 (71.4) | 63 (81.8) | |
| Missing | 1 (0.6) | 0 (0.0) | 0 (0.0) | 1 (1.3) | |
|
| |||||
| Myoinvasion | 0.0006 | ||||
| <50% | 93 (53.1) | 50 (65.8) | 4 (19.1) | 39 (50.0) | |
| >50% | 82 (46.9) | 26 (34.2) | 17 (81.0) | 39 (50.0) | |
|
| |||||
| ITC detection method | <.0001 | ||||
| H&E | 85 (48.9) | 24 (31.6) | 6 (30.0) | 55 (70.5) | |
| Cytokeratin | 89 (51.2) | 52 (68.4) | 14 (70.0) | 23 (29.5) | |
| Missing | 0 (0.0) | 1 (4.8) | 0 (0.0) | ||
|
| |||||
| Stage | 0.001 | ||||
| 1A | 85 (48.6) | 47 (61.8) | 3 (14.3) | 35 (44.9) | |
| 1B | 69 (39.4) | 25 (32.9) | 12 (57.1) | 32 (41.0) | |
| 2 | 21 (12.0) | 4 (5.3) | 6 (28.6) | 11 (14.1) | |
|
| |||||
| Staging method | 0.0003 | ||||
| SLN only | 90 (51.4) | 38 (50.0) | 5 (23.8) | 47 (60.3) | |
| SLN+pelvic LND | 38 (21.7) | 20 (26.3) | 11 (52.4) | 7 (9.0) | |
| SLN+ pelvic+aortic LND | 47 (26.9) | 18 (23.7) | 5 (23.8) | 24 (30.8) | |