Table 3.

Interactive Associations Between Parasomnia, Preterm Birth and Current Wheeze and Ever Asthma

		Current Wheeze						Ever Asthma
		Crude Model		Adjusted Model I		Adjusted Model II		Crude Model		Adjusted Model I		Adjusted Model II
		OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Parasomnia * Preterm		1.31 (0.93–1.85)	0.128	1.47 (1.00–2.17)	0.051	1.48 (1.01–2.19)	0.049	1.29 (0.91–1.81)	0.148	1.30 (0.89–1.90)	0.174	1.29 (0.89–1.89)	0.183
Parasomnia	Preterm
No	No	Ref		Ref		Ref		Ref		Ref		Ref
No	Yes	1.40 (1.10–1.79)	0.007	1.44 (1.09–1.89)	0.010	1.42 (1.07–1.90)	0.017	1.23 (0.97–1.56)	0.084	1.24 (0.96–1.61)	0.100	1.29 (0.98–1.69)	0.069
Yes	No	2.20 (1.97–2.45)	<0.001	1.69 (1.49–1.92)	<0.001	1.66 (1.46–1.88)	<0.001	1.91 (1.72–2.12)	<0.001	1.59 (1.41–1.79)	<0.001	1.56 (1.38–1.75)	<0.001
Yes	Yes	4.02 (3.14–5.13)	<0.001	3.59 (2.72–4.74)	<0.001	3.50 (2.61–4.70)	<0.001	3.03 (2.36–3.87)	<0.001	2.57 (1.95–3.39)	<0.001	2.60 (1.94–3.47)	<0.001
		RERI, 1.43 (0.41–2.45); AP, 0.41 (0.21–0.60); SI, 2.33 (1.36–3.99)						RERI, 0.75 (0.01–1.50); AP, 0.29 (0.06–0.52); SI, 1.90 (1.02–3.52)

Notes: Statistically significant results (p < 0.05) are in bold. Parasomnia, preterm, and parasomnia *Preterm are mutually adjusted for each other. Model I adjusted for child age, overweight/obesity, gender, mother’s educational level, father’s educational level, family income, family structure, family allergic history, family sleep disorder history; Model II further adjusted for maternal age at delivery, maternal pre-pregnancy overweight, maternal smoking, maternal drinking, negative life event, cesarean delivery, low birthweight, multiple pregnancy, breastfeeding, passive smoking, pet keeping during first year of life.

Abbreviations: OR, odd ratio; CI, confidence interval; RERI, relative excess risk due to interaction; AP, proportion attributable to interaction; SI, synergy index.