Fig. 5. Intramotif positional preference of mTET3-induced demethylation in cultured mESCs.

(A) Demethylation kinetics of the four nucleotides in a given CG containing hexamer position (shown are −1 and + 1 positions flanking the central CG). (B) Proportion of nucleotides that are demethylated the fastest (left) and slowest (right) at each motif position when all other nucleotides in that motif are kept constant.