Table 1:

Tissue expression patterns and proposed function of various Myosin 1 isoforms in vertebrates.

Myosin	Expression in Vertebrate Tissue	Reported/Proposed Function	References
Myosin 1A	Intestinal epithelia	Actin-based motor protein; Maintaining brush-border integrity in intestinal epithelium; Protein trafficking from basolateral to apical membranes	(78, 130)
Myosin 1B	Heart, brain, lung, liver and intestine	Intracellular localization; Transport of internalized molecules to lysosomes	(76, 83, 131)
Myosin 1C	Widely distributed; Cytoplasmic as well as nuclear isoforms. Mouse Retina Upper tip link in the ear inner hair cells	Transcription initiation; Intracellular vesicle transport to plasma membrane (in mice); may form adaptation motor complex; role in inner ear function; Opsin transport to Photoreceptor Outer Segments and Visual Function; Mouse Vitreous; Auditory function, hair cell adaption and acting binding; Missense mutations reported in patients with sensorineural hearing loss	(132, 124, 136, 138) (149, 125–129)
Myosin 1D	Neurons of brainstem and spinal cord	Moves transferrin along the actin filaments; Membrane protein trafficking (proposed)	(82)
Myosin 1E	Widely expressed; Localizes in renal podocytes	Podocyte function and integrity of glomerular filtration membrane	(77, 134)
Myosin 1F	Spleen, Lymph nodes and thymus; Selectively expressed in neutrophils	Neutrophil motility; deafness in humans	(84, 85, 135)
Myosin 1G	Lymphocytes	Associated with cell membrane plasticity and motility	(137, 138)
Myosin 1H	Testis	Polymorphisms in MYO1H causes mandibular prognathism	(88)