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. 2022 Aug 6;11(8):e12255. doi: 10.1002/jev2.12255

FIGURE 1.

FIGURE 1

The dual‐modified functional sEVs loaded chemotherapy drug delivery system for the treatment of central nervous system diseases. Angiopep‐2 and TAT peptide are modified to sEVs membrane surface to obtain engineered sEVs with dual targeting and cell‐penetrating functions, which could permeate the BBB, target the glioma, and penetrate the tumour, so as to achieve efficient and specific chemotherapy for glioma