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. 2022 Sep 7;11:e75715. doi: 10.7554/eLife.75715

Figure 5. Transcriptome analysis predicts unique pharmacological vulnerabilities.

Druggable kinases positively enriched in GSEA hallmarks identified in Figure 3D (blue KrasLSL-natG12D/+, red KrasLSL-comQ61R/+). * Adjusted p-value<5%.

Figure 5.

Figure 5—figure supplement 1. Differential expression of known transcription factors of genes enriched in the GSEA hallmarks identified in the transcriptome of lung tissue upon activating the KrasLSL-natG12D and KrasLSL-comQ61R alleles.

Figure 5—figure supplement 1.

(A, B) Mean ± SEM of log2 fold change (Log2FC) differential expression of genes (Kras LSL-comQ61R versus Kras LSL-natG12D) activated by transcription factors enriched in GSEA hallmarks of (A) Kras LSL-natG12D, and (B) Kras LSL-comQ61R transcriptome (adjusted p-value less than 5%). +, genes common to more than one GSEA hallmark.