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. 2022 Aug 24;12:979748. doi: 10.3389/fonc.2022.979748

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Copyright © 2022 Xu, Abramov, Belykh, Mignucci-Jiménez, Park, Eschbacher and Preul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar chart showing a comparison of overall mean (SD) brightness and contrast of in vivo and ex vivo images. In vivo images had a mean brightness of 112.1 (26.9) and contrast of 44.7 (8.0). Ex vivo images had a mean brightness of 60.7 (23.6) and a contrast of 26.8 (7.9). In vivo images have higher brightness and contrast than ex vivo images (p < 0.001). Values are reported in optical density units defined by the Fiji software. Asterisk indicates p < 0.001. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.