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. 2022 Aug 24;12:979748. doi: 10.3389/fonc.2022.979748

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Copyright © 2022 Xu, Abramov, Belykh, Mignucci-Jiménez, Park, Eschbacher and Preul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar charts showing mean brightness and contrast of images from glioma (A), meningioma (B), and intracranial metastatic tumor (C) cases from both studies. The mean brightness and contrast of the in vivo images from glioma (brightness: 105.2 [25.8] vs. 60.6 [8.1], p < 0.001; contrast: 43.2 [24.9] vs. 26.5 [6.9], p < 0.001), meningioma (brightness: 106.3 [26.0] vs. 60.0 [18.8], p < 0.001; contrast: 36.7 [8.0] vs. 31.7 [8.9], p < 0.001), and intracranial metastatic tumor (brightness: 118.2 [26.5] vs. 70.6 [25.1], p < 0.001; contrast: 49.6 [4.9] vs. 30.1 [6.8], p < 0.001, Figure 6C values are significantly higher than those of the ex vivo images. Values are reported in optical density units defined by Fiji software. Asterisk indicates p < 0.001. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.