Table 2.
Diagnostic performance of confocal laser endomicroscopy (CLE) in all cases and glioma cases.
| Variable | Ex vivo study | In vivo study | ||
|---|---|---|---|---|
| All Samples | Glioma | All Samples | Glioma | |
| Sensitivity | 72 (62-80) | 66 (55-76) | 90 (78-96) | 91 (72-98) |
| Specificity | 90 (67-98) | 94 (69-100) | 94 (74-100) | 100 (65-100) |
| Positive predictive value | 97 (90-100) | 98 (89-100) | 97 (87-100) | 100 (84-100) |
| Negative predictive value | 38 (25-54) | 37 (23-53) | 81 (60-92) | 78 (45-96) |
All data are presented as percent and 95% confidence intervals.
Permanent hematoxylin and eosin–stained section pathology was used as the gold standard. All CLE digital biopsies were interpreted by a single experienced neuropathologist.