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Fused [18F] PI-2620 τ-PET and T1 MPRAGE MR imaging from subjects 66 (A) and 78 years of age (B) with semantic PPA. Notably, [18F] PI-2620 has a low affinity for monoamine oxidase, and subject A demonstrates no focal increased tracer uptake. However, subject B shows binding spanning the anterior and lateral temporal lobes (left greater than right) with corresponding atrophy on MR imaging. Adapted with permission from Mormino et al.59
