FIG 14.

[¹⁸F] flortaucipir in nfvPPA. A, On voxelwise comparison with healthy controls, agPPA demonstrates increased uptake in the left-greater-than-right frontal operculum; middle and inferior frontal gyri; and left superior frontal gyrus (pFWE < .05). B, The W score frequency map demonstrates elevated W scores above 1.65 in the bilateral middle frontal gyri and frontal operculum in approximately two-thirds of patients scanned, with voxels above 1.65 in 8 of 11 patients in peak areas. C, ROI analyses reveals group differences in those with in nfvPPA compared with controls in the bilateral pars opercularis (left, P = .0001; right, P = .0018), pars triangularis (left, P = .0016; right, P = .0029), precentral gyrus (left, P = .003; right. P = .0112), and superior frontal gyrus (left, P = .03; right, P = .045). Adapted with permission from Tsai et al.⁸¹