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. 2022 Aug 22;226(10):1704–1711. doi: 10.1093/infdis/jiac348

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Transmission clusters with sequences unique to Boston Medical Center (BMC). A, Network representation of all sequences (nodes) with edges representing potential transmission. Starting with the earliest sequence as a cluster, subsequent sequences join into a cluster if they are within 1 single-nucleotide polymorphism (SNP) of a cluster member, occur within 14 days of a cluster member, and, for 1-SNP connections, are not isogenic to any sequences observed in GISAID. Dark edges show surviving connections; lighter edges, connections between genomically similar sequences that do not satisfy the other conditions. Thicker and thinner edges reflect 0-SNP and 1-SNP differences between sequences, respectively. Healthcare worker sequences unique to BMC are shown in orange; those isogenic to sequences in GISAID, in black. B, Incidence of transmission clusters over time.