Figure 2.

Effect of human immunodeficiency virus (HIV) status and suppression on antibody neutralization capacity. A, Neutralization of wave-concordant Beta virus and cross-neutralization of ancestral D614G and Delta virus by plasma samples from HIV-negative individuals and HIV-suppressed people with HIV (PWH). Friedman’s test was used to compare matched participant data across the different variants. *P = .03; ***P < .001. Abbreviation: FRNT₅₀, 50% focus reduction neutralization titer. B, Neutralization of D614G, Beta, and Delta viruses by plasma samples from viremic PWH. C–E, Neutralization titers of plasma samples from HIV-negative participants (Neg) and HIV-suppressed PWH (Sup) compared with viremic PWH (Vir) for ancestral D614G, Beta, and Delta viruses. Error bars show geometric means and geometric standard deviations. Dotted lines in A­–E show the minimum tested dilution of 1:20 for the neutralization assay. *P = .0499; Mann-Whitney test was used to compare patient groups. F–H, Fractions of HIV-negative individuals and HIV-suppressed and viremic PWH who had detectable neutralization (above limit of quantification) of ancestral D614G, Beta, and Delta viruses. The fraction of viremic PWH able to neutralize was lower but with borderline significance (P = .0499; Fisher exact test).