Table 2.

Summary of temporal-informed PheWAS in postacute COVID-19

Phecodea	Description	Odds ratio	95% CI	P value	No. cases	No. controls
512.9	Other dyspnea	3.04	(2.52–3.68)	5.54 × 10−31	811	93 936
512.7	Shortness of breath	2.49	(2.09–2.96)	2.73 × 10−24	988	93 936
569.2	Gastrointestinal complications of surgery	6.54	(4.38–9.75)	3.32 × 10−20	116	166 825
278.11	Morbid obesity	2.35	(1.93–2.86)	1.49 × 10−17	624	154 861
649	Conditions of the mother complicating pregnancy, childbirth, or the puerperium	3.85	(2.76–5.38)	2.66 × 10−15	169	95 518
509.1	Respiratory failure	7.09	(4.35–11.6)	3.89 × 10−15	101	157 792
136	Other infectious and parasitic diseases	9.20	(5.14–16.5)	8.43 × 10−14	54	181 966
359.2	Myopathy	20.5	(9.24–45.4)	9.99 × 10−14	33	174 863
427.9	Palpitations	2.14	(1.75–2.61)	1.40 × 10−13	628	137 086
418.1	Precordial pain	3.21	(2.35–4.39)	2.71 × 10−13	278	138 537
418	Nonspecific chest pain	2.01	(1.66–2.43)	1.19 × 10−12	746	138 537
646	Other complications of pregnancy NEC	5.91	(3.55–9.83)	7.89 × 10−12	69	99 542
585.1	Acute renal failure	3.15	(2.26–4.38)	9.49 × 10−12	309	157 475
427.21	Atrial fibrillation	2.62	(1.98–3.48)	2.56 × 10−11	443	137 086
1010	Other tests	3.17	(2.19–4.60)	1.21 × 10−9	155	169 347
644	Anemia during pregnancy	7.43	(3.74–14.7)	9.91 × 10−9	38	101 761
1010.6	Reproductive and maternal health services	1.75	(1.44–2.12)	9.99 × 10−9	591	172 787
638	Other high-risk pregnancy	2.19	(1.67–2.86)	1.34 × 10−8	312	178 757
350.1	Abnormal involuntary movements	2.53	(1.83–3.48)	1.46 × 10−8	256	170 487
671	Venous/cerebrovascular complications & embolism in pregnancy and the puerperium	21.5	(7.25–63.7)	3.10 × 10−8	17	103 586
649.1	Diabetes or abnormal glucose tolerance complicating pregnancy	4.73	(2.68–8.34)	7.77 × 10−8	57	95 518
782.3	Edema	2.08	(1.59–2.73)	8.34 × 10−8	424	168 184
452.2	Deep vein thrombosis [DVT]	3.23	(2.09–4.99)	1.26 × 10−7	138	162 711
285	Other anemias	2.05	(1.56–2.68)	1.85 × 10−7	473	146 505
781	Symptoms involving nervous and musculoskeletal systems	3.07	(2.01–4.68)	1.88 × 10−7	151	180 070
1013	Asphyxia and hypoxemia	5.51	(2.89–10.5)	2.07 × 10−7	52	175 439
292	Neurological deficits	2.39	(1.72–3.32)	2.31 × 10−7	242	162 234
599.2	Retention of urine	2.93	(1.95–4.41)	2.45 × 10−7	184	149 134
514	Abnormal findings examination of lungs	2.29	(1.64–3.20)	9.86 × 10−7	350	163 569
587	Kidney replaced by transplant	32.4	(7.99–131.)	1.12 × 10−6	22	157 475
401.1	Essential hypertension	1.42	(1.23–1.64)	2.17 × 10−6	1698	122 907
278.1	Obesity	1.70	(1.36–2.12)	2.33 × 10−6	566	154 861
327.32	Obstructive sleep apnea	1.69	(1.36–2.11)	2.51 × 10−6	669	150 608
420.1	Myocarditis	10.0	(3.83–26.2)	2.67 × 10−6	20	177 003
250.2	Type 2 diabetes	1.77	(1.38–2.25)	4.75 × 10−6	572	148 033
348.8	Encephalopathy, not elsewhere classified	6.23	(2.76–14.1)	1.10 × 10−5	32	160 519
653	Problems associated with amniotic cavity and membranes	8.04	(3.15–20.5)	1.32 × 10−5	19	97 532
502	Postinflammatory pulmonary fibrosis	5.47	(2.49–12.0)	2.26 × 10−5	40	157 792
284.1	Pancytopenia	3.25	(1.87–5.66)	2.96 × 10−5	94	146 505
38.3	Bacteremia	8.03	(2.95–21.9)	4.54 × 10−5	19	166 009
292.3	Memory loss	1.99	(1.43–2.77)	5.09 × 10−5	287	162 234
285.21	Anemia in chronic kidney disease	3.10	(1.79–5.36)	5.22 × 10−5	104	146 505
54	Herpes simplex	3.66	(1.95–6.85)	5.22 × 10−5	54	149 827

^aA list of ICD-10-CM codes included in each phecode is available at: https://phewascatalog.org/phecodes_icd10cm.³²