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. 2022 Aug 31;609(7926):369–374. doi: 10.1038/s41586-022-05140-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Percentages of cluster 1 (C1) and cluster 2 (C2) in two donor samples prepared by different methods. C1 and C2 were generated by clustering cells on the basis of expression of CD8⁺ memory and dysfunction/cytotoxicity marker genes, respectively. P1, patient 1; P2, patient 2. b, GSEA of CD8⁺ T cells comparing AAVS1-19bbz and PD1-19bbz cells. Enriched gene sets in PD1-19bbz cells and the normalized enrichment score (NES) are shown. c,d, Violin plots showing the expression of memory (c) and dysfunction/cytotoxicity (d) genes in CD8⁺CAR⁺ cells from three patients before and after infusion. Data for the sample from patient 3 taken after 28 d of treatment are not shown owing to an unreliable low CAR⁺ cell number. D, days after infusion; IP, infusion product. e, GSEA comparing CD8⁺CAR⁺PD1⁺ and CD8⁺CAR⁺PD1^– cells from three patients after 7 or 12 d of infusion. The top six most enriched gene sets in CD8⁺CAR⁺PD1^– cells and the NES are shown.

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