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. 2022 Aug 17;609(7926):354–360. doi: 10.1038/s41586-022-05105-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — Adult 8-12 weeks Myb^fl/flCd4^Cre (Myb-cKO) and littermate Myb^fl/fl control (Ctrl) mice were euthanized, and T cell populations were analysed in the thymus, spleen and lymph nodes. Flow cytometry and quantifications showing (a–c) frequencies of thymocyte subsets, (d–f) frequencies and abundance of mature splenic CD8⁺ T cells, (g) surface expression of CD127 (IL-7R), CCR7 and CD25 (IL-2R) of splenic CD8⁺ T cells and (h, i) frequencies of mature CD8⁺ T cells residing in lymph nodes. (h). Dots in graphs represent individual mice; box plots indicate range, interquartile and median. All data are representative of two independent experiments. P values are from two-tailed unpaired t-tests (d, f–h) and Mann–Whitney tests (a, c, e, i); P > 0.05, not significant (n.s.).

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