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. 2022 Jun 29;609(7926):400–407. doi: 10.1038/s41586-022-04838-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Nucleotide loaded RAS samples were analyzed by mass spectrometry, which found complete loading of GDP or GCP for each sample. b, SEC traces showing three-way complex formation between KRASΔHVR (top left), HRAS (bottom left), NRAS (top right) and KRAS4B (bottom right) in the presence of GCP loaded RAS (blue) but not GDP loaded RAS (red), and associated SDS-PAGE analysis of SEC fractions. Results representative of two independent experiments.