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. 2022 Aug 31;609(7926):341–347. doi: 10.1038/s41586-022-05157-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 12 — a. Semi-synthesis of vinblastine by chemical coupling of catharanthine and vindoline. Two methods were used for the coupling of vindoline and catharanthine, a photo-chemical coupling under near-UV light³⁸ followed by reduction using NADH, and a chemical coupling using FeCl₃, followed by reduction using NaBH₄²; b. Representative chromatograms of vinblastine standard (left), and vinblastine and anhydrovinblastine produced from the Fe(III)-based chemical coupling using yeast-produced catharanthine and vindoline (right). FMN: flavin mononucleotide.