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. 2022 Aug 15;14(8):5243–5262.

Figure 2.

Figure 2

A. Immunohistochemical results on knee joints of rats in each group. B-F. The results showed that the expression of type II collagen (COL2) decreased after ACLT+DMM modeling, while the expression levels of MMP-13 and IL-6 positive cells increased, and the expression levels of p16 and P21 positive cells also significantly increased. After the application of PTE, the expression of type II collagen was increased, and the expression levels of MMP-13, IL-6, P16, and P21 positive cells were also significantly decreased. These results indicate that PTE has anti-inflammatory and anti-aging effects in OA model rats. G. Elisa *: P < 0.05, **: P < 0.01, ***: P < 0.001, ****: P < 0.0001.