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. 2022 Aug 15;14(8):5243–5262.

Figure 8.

Figure 8

A. Immunofluorescence showed that IL-1β inflammation induced nuclear inward migration of P65, and p65 was re-transferred to chondrocyte cytoplasm under PTE. These results suggest that PTE can play an anti-inflammatory and anti-aging role by inhibiting nuclear translocation of P65. Group A: CG; B; IL-1β (10 ng/ mL); C: IL-1β+PTE (10 μmol/L); D: IL-1β+PTE (20 μmol/L). B. Molecular docking results showed that PTE could stably bind to the amino acid residues of PI3K (Glu-628, ASP-584, ARG-389) and play a role in inhibiting the activation of PI3K, with a binding energy of -6.89 kcal/mol.