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Schematic diagram of MN mechanism hypothesis. Environmental factors (toxicity, inflammation, infection, etc.) lead to up-regulation of renal TP53 and down-regulation of SLC2A3 in PBMCs. Changes in the kidney expose podocyte target antigens. Changes in peripheral immune cells allow the persistence of a humoral immune response with IgG4 as the main antibody. Created with BioRender.com. Agreement number: SO245P2AW5.
