Table 2.

GO for DEGs between the control and IS groups

Category	Term	Count	Gene ratio	p-value	Fold enrichment	Genes
BP	GO:0042981	4	12.90	0.00422	11.68	EGR1, DUSP1, BCL10, ZNF420
	Regulation of apoptotic process
BP	GO:0051384	3	9.68	0.00452	28.70	DUSP1, KRAS, PTGS2
	Response to glucocorticoid
BP	GO:0038095	3	9.68	0.0307	10.48	IGKC, KRAS, BCL10
	Fc-epsilon receptor signaling pathway
BP	GO:0071479	2	6.45	0.0469	40.12	TANK, SPIDR
	Cellular response to ionizing radiation
BP	GO:0042517	2	6.45	0.0572	32.73	SOCS3, OSM
	Positive regulation of tyrosine phosphorylation of Stat3 protein
BP	GO:0034644	2	6.45	0.0660	28.27	NOC2L, PTGS2
	Cellular response to UV
BP	GO:0040008	2	6.45	0.0790	23.47	SOCS3, OSM
	Regulation of growth
BP	GO:0007249	2	6.45	0.0889	20.73	BCL10, TANK
	I-kappaB kinase/NF-kappaB signaling
CC	GO:0005737	13	41.94	0.0764	1.56	EGR1, DUSP1, ZFAND5, BCL10, NOC2L, PTGS2, TANK, SOCS3, FAM200A, FTH1, SIK3, KRAS, VIM
	Cytoplasm
CC	GO:0005634	13	41.94	0.0966	1.51	EGR1, WTAP, DUSP1, MYNN, YOD1, BCL10, NOC2L, PTGS2, SAMSN1, STK17B, FTH1, ZNF404, ANAPC5
	Nucleus
CC	GO:0005829	10	32.26	0.0544	1.90	ANKRD28, SOCS3, FTH1, KRAS, YOD1, ANAPC5, BCL10, VIM, TANK, SAMSN1
	Cytosol
MF	GO:0005515	20	64.52	0.0673	1.33	ANKRD28, SRGN, EGR1, WTAP, DUSP1, ZFAND5, YOD1, BCL10, NOC2L, PTGS2, TANK, SPIDR, SOCS3, FAM200A, FTH1, SIK3, ZNF404, KRAS, VIM, ZNF420
	Protein binding
MF	GO:0046872	8	25.81	0.0478	2.25	EGR1, MYNN, ZNF404, KRAS, YOD1, PTGS2, TANK, ZNF420
	Metal ion binding
MF	GO:0031625	3	9.68	0.0815	6.08	YOD1, BCL10, TANK
	Ubiquitin protein ligase binding

GO : Gene Ontology, DEGs : differentially expressed genes, BP : biological process, CC : cellular component, UV : ultraviolet, MF : molecular function