Trends in route(s) of fentanyl administration during exposure. The prevalence of ingestion increased between 2015 and 2021 between 44.0% and 47.2% (p< .001), as did the prevalence of injection (from 6.7% to 9.6%, p= .012), and inhalation (from 5.7% to 29.9%, p< .001). The prevalence of dermal route of administration, however, decreased from 40.2% to 5.7% (p= .013).