TABLE 1.
Phosphorylated sites identified by mass spectrometry
| TDP‐43 residue | FTLD‐TDP Type A | FTLD‐TDP Type B | Controls | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | Case 8 | Case 9 | Case 10 | |
| S20 | ‐ | ‐ | ‐ | ‐ | ||||||
| T25 | ‐ | ‐ | ‐ | ‐ | ||||||
| T88 | ||||||||||
| S91 | ||||||||||
| S92 | ||||||||||
| S183 | ‐ | |||||||||
| S212 | ‐ | ‐ | ||||||||
| Y214 | ‐ | ‐ | ||||||||
| S242 | ‐ | ‐ | ‐ | |||||||
| S254 | ‐ | ‐ | ‐ | |||||||
| S258 | ‐ | ‐ | ‐ | |||||||
| S266 | ‐ | ‐ | ‐ | |||||||
| S273 | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ||||
| S305 | ‐ | ‐ | ||||||||
| S342 | ||||||||||
| S347 | ||||||||||
| S350 | ||||||||||
| S369 | ‐ | ‐ | ||||||||
| S373 | ‐ | ‐ | ||||||||
| Y374 | ‐ | ‐ | ||||||||
| S375 | ‐ | |||||||||
| S377 | ‐ | |||||||||
| S379 | ‐ | |||||||||
| S387 | ||||||||||
| S389 | ||||||||||
| S393 | ||||||||||
| S395 | ||||||||||
| S403 | ‐ | ‐ | ||||||||
| S404 | ‐ | ‐ | ||||||||
| S410 | ‐ | ‐ | ||||||||
Note: Green cell indicates a confidently localised phosphosite (AScore ≥10). Yellow cell indicates a potentially phosphorylated site–phosphorylated peptide with ambiguous localisation. Grey cell indicates that only an unmodified residue was identified. ‘‐’ indicates a residue not identified by LC–MS/MS. AScore is a localisation score assigned to modifications on peptide as the −10 log of a p value corresponding to the probability that the modification occurs at the reported position compared with other possible positions.