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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2022 Sep 1;80(3):334–341. doi: 10.1097/FJC.0000000000001324

Figure 3. Balancing pools of cAMP signaling to PLCε by PDE isoforms.

Figure 3.

Distinct cAMP pools are differentially controlled by PDEs 2/9 and PDE3. PDE3 prevents cAMP diffusion to the nuclear envelope/Golgi limiting activation of PLCε at that location. A distinct pool of cAMP regulated by PDEs 2/9 at plasma membrane opposes the activity of PLCε through a PKA dependent mechanism46.