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. 2022 Sep 7;5:923. doi: 10.1038/s42003-022-03897-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A Spearman correlation between the four most abundant Staphylococcus species and C. acnes SLST classes found on the skin was performed. The colour code illustrates the correlation coefficient; blue colour represents positive correlation (0 to 1) and red colour inverse correlation (−1 to 0). For instance, this revealed a positive (and statistically significant) correlation between S. epidermidis and K-class C. acnes and an inverse correlation (albeit not statistically significant) between S. epidermidis and A-class C. acnes. The correlation analysis is only shown for the four most frequently detected staphylococci and C. acnes SLST classes; correlation analysis for less frequent staphylococcal species and C. acnes SLST classes that are detected in relatively few samples is not reliable. (FDR-adjusted p-value; *p ≤ 0.05). b The mean relative abundances of C. acnes SLST classes on skin sites with (+) and without (−) antimicrobially active staphylococcal strains are depicted. The presence of staphylococcal strains with antimicrobial activity led to a decrease of the relative abundance of A-class C. acnes. c Boxplots of relative abundances of the six C. acnes SLST classes on skin sites with (+) and without (−) antimicrobially active staphylococcal strains (n = 21 (+) and n = 92 (−), respectively) are shown (FDR-adjusted p-value, **p ≤ 0.01. Unpaired Wilcoxon test). Middle lines of boxplots indicate the median. Lower and upper lines represent the first and third quartiles. Whiskers show the 1.5x inter-quartile ranges.