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. 2022 Sep 7;5:884. doi: 10.1038/s42003-022-03808-9

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Genomic changes present in cancer genomes. b Number of cells (y-axis) with N reads covering point mutations (x-axis), separated by low (NB neuroblastoma) and high (RCC renal cell carcinoma) mutation burden. c Number of cells (y-axis) with N reads covering heterozygous single nucleotide polymorphisms (SNP) (x-axis). d Overview of using allelic shifts representing copy-number changes to detect cancer cells.