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. 2022 Sep 7;5:884. doi: 10.1038/s42003-022-03808-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a UMAP of RCC single cell transcriptomes showing patient (shading), cell type (contours and labels), and patient composition (barplots). Inset shows expression of RCC marker CA9. PTC proximal tubular cells derived from normal biopsies. b Cancerous (red) and non-cancerous (grey) cell fraction excluding ambiguous cells by cell type (x-axis) and sample/region (y-axis) called by CopyKAT (left) or alleleIntegrator (right). c Copy-number profile for PD37228 tumour (left) and proximal tubular (right) clusters from normalised averaged expression (top panels, solid black line) and allelic ratio (bottom panel, one dot per bin with ~500 reads), with true copy-number changes from DNA (red shading). d–f As per (a–c) but for neuroblastoma.