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. 2022 Sep 7;13:5268. doi: 10.1038/s41467-022-32962-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Summary of the top 100 common mutated genes in the ESCC-META dataset. The dot heat of left panel indicated the mutational importance estimated by four approaches, and the red stars labeled the significantly mutated genes (n = 22) in combined selection. The bar plot of middle panel indicates the mutational frequency. The dot plot of right panel indicates the major related pathway. b The oncoplot of the 22 significantly mutated genes in ESCC-META cohort. c The circle chart to indicate the recurrent SNVs in ESCC-META cohort. Each point represented one recurrent mutational site in genome, and the relative height indicate the recurrent frequency. The inner part of the circle linked the significant interactions of gene-pairs, in which the blue links indicated mutually exclusive patterns and the red links indicated co-occurring patterns. Source data are provided as a Source Data file.