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. 2022 Sep 7;13:5268. doi: 10.1038/s41467-022-32962-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Comparative bar plot of most significantly varied genes between old patients and young patients. The two-side Fisher’s exact test was used to indicate the significance, and * indicating p < 0.05, **p < 0.01, ***p < 0.001. b The proportion of NOTCH1 mutated patients in different groups of diagnostic age. c The mutational frequencies in tumors from different thoracic part. The upper panel indicated genes more commonly mutated in upper part, while the lower panel presented lower-part prone mutations. The two-side Fisher’s exact test was used to indicate the significance, and * indicating p < 0.05, **p < 0.01, ***p < 0.001. d The top 15 enriched pathways from GO analysis of upper part prone genes (upper part) or lower-part prone genes (lower part). The labeled * represents for p (adjusted) <0.05, ** for p (adjusted) <0.01. e Survival plots of some significant genes in early or late-stage patients. The two-side log-rank test was used to indicate the significance. Source data are provided as a Source Data file.