TABLE 3.
Fetal glucose, lactate, blood gas, and hormone concentrations after 1-week infusion of oIGF-1 or saline (SAL).
| SAL (n = 6) | oIGF-1 (n = 6) | p-values | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Final | Baseline | Final | Time | Group | Interaction | |
| Glucose (mg·dL−1) | 15.63 ± 0.53 | 14.36 ± 0.71 | 16.53 ± 1.11 | 13.34 ± 1.82 | 0.0406 | 0.9648 | 0.3365 |
| Lactate (mmol·L−1) | 1.54 ± 0.06 | 1.42 ± 0.12 | 1.58 ± 0.03 | 1.68 ± 0.26 | 0.9303 | 0.3062 | 0.4887 |
| pH | 7.34 ± 0.01 | 7.32 ± 0.02 | 7.34 ± 0.01 | 7.33 ± 0.02 | 0.2247 | 0.9158 | 0.5541 |
| PaCO2 (mmHg) | 48.78 ± 1.11 | 51.40 ± 1.68 | 49.40 ± 0.70 | 51.85 ± 1.11 | 0.0427 | 0.6899 | 0.9407 |
| PaO2 (mmHg) | 21.18 ± 0.85 | 20.15 ± 1.27 | 21.02 ± 1.41 | 19.85 ± 1.19 | 0.3310 | 0.8616 | 0.9518 |
| Hematocrit (%) | 34.3 ± 1.19 | 33.25 ± 0.90 | 34.25 ± 0.73 | 32.55 ± 0.90 | 0.0180 | 0.7842 | 0.4807 |
| O2 saturation (%) | 52.32 ± 2.69 | 48.57 ± 5.26 | 49.53 ± 5.19 | 47.47 ± 5.65 | 0.4683 | 0.7386 | 0.8317 |
| O2 content (mmol·L−1) | 3.57 ± 0.21 | 3.22 ± 0.37 | 3.35 ± 0.35 | 2.93 ± 0.32 | 0.1385 | 0.5293 | 0.8914 |
| Cortisol (ng·mL−1)Δ | 24.8 ± 7.2 | 19.7 ± 4.2 | 22.5 ± 6.1 | 25.6 ± 5.9 | 0.8731 | 0.7704 | 0.5184 |
| Norepinephrine (pg·mL−1) | 1,022.5 ± 353.1 | 897.2 ± 394.6 | 1,144.2 ± 400.0 | 1,455.0 ± 301.9 | 0.4295 | 0.5148 | 0.0816 |
Values represent mean ± SEM. p-values determined by two-way repeated measures ANOVA for the effects of time, group (SAL, oIGF-1), and interaction. Δ indicates n = 4 per group.
Bolded values indicates significant p values.