TABLE 4.

Fetal concentrations of amino acids after 1-week infusion of oIGF-1 or saline (SAL).

	SAL (n = 6)		oIGF-1 (n = 6)		p-values
	Baseline	Final	Baseline	Final	Time	Group	Interaction
Alanine	211 ± 13	246 ± 22	192 ± 15	196 ± 46	0.4039	0.2963	0.4935
Arginine	90 ± 12	122 ± 5	87 ± 14	68 ± 9*	0.3360	0.0563	0.0035
Asparagine	33 ± 3	43 ± 6	32 ± 2	36 ± 5	0.0559	0.4549	0.3572
Aspartate	28 ± 7	27 ± 5	25 ± 6	21 ± 2	0.3827	0.5244	0.5745
Cysteine	18 ± 2	20 ± 2	16 ± 2	15 ± 2	0.7171	0.1941	0.4644
Glutamate	28 ± 3	29 ± 4	24 ± 2	24 ± 3	0.9467	0.2966	0.7835
Glutamine	390 ± 19	416 ± 43	361 ± 14	304 ± 36	0.4627	0.0967	0.0664
Glycine	318 ± 54	378 ± 57	325 ± 43	460 ± 60	0.0521	0.4920	0.4207
Histidine	37 ± 5	51 ± 7	32 ± 4	32 ± 5*	0.0285	0.1122	0.0285
Isoleucine	84 ± 6	88 ± 5	82 ± 8	76 ± 6	0.8406	0.4007	0.2311
Leucine	110 ± 8	124 ± 8	105 ± 9	101 ± 9	0.4103	0.1852	0.1767
Lysine	60 ± 10	85 ± 12	55 ± 6	44 ± 7*	0.1691	0.0938	0.0037
Methionine	93 ± 9	86 ± 13	89 ± 10	68 ± 9	0.0331	0.4270	0.2791
Ornithine	53 ± 6	65 ± 7	54 ± 8	38 ± 4*	0.6517	0.1014	0.0244
Phenylalanine	97 ± 5	110 ± 7	97 ± 4	109 ± 9	0.0187	0.9547	0.9979
Proline	116 ± 7	151 ± 17	119 ± 8	110 ± 12	0.2826	0.1313	0.0873
Serine	531 ± 41	530 ± 38	521 ± 43	433 ± 41	0.2314	0.2656	0.2435
Taurine	78 ± 19	97 ± 42	72 ± 14	77 ± 10	0.3791	0.6822	0.5940
Threonine	274 ± 43	293 ± 40	234 ± 27	217 ± 26	0.9546	0.2471	0.2152
Tryptophan	46 ± 2	49 ± 2	40 ± 4	43 ± 2	0.2085	0.1196	0.8083
Tyrosine	120 ± 8	120 ± 12	126 ± 5	117 ± 9	0.4822	0.8971	0.4885
Valine	329 ± 18	365 ± 24	320 ± 24	313 ± 21	0.5671	0.1516	0.3846
Summed	3,147 ± 148	3,495 ± 223	3,009 ± 115	2,903 ± 195	0.3657	0.1164	0.0626

Amino acid concentrations are reported as µmol·L⁻¹. Values represent mean ± SEM. p-values determined by two-way repeated measures ANOVA for the effects of time, group (SAL, oIGF-1), and interaction. *Indicates significantly lower (p ≤ 0.05) compared to final SAL by Bonferroni’s post hoc test.

Bolded values indicates significant p values.