TABLE 2.
The target cancer signaling pathways by acetylation modifications in HCC.
| HATs/HDACs | Target Signaling Pathways | Cellular Function | References |
|---|---|---|---|
| P300 | TGF-β1 signaling | Cell proliferation | Guo et al. (2021) |
| MOF | Estrogen receptor α signaling pathway | Cell growth, migration, and invasion | Wei et al. (2021) |
| N-α-acetyltransferase 20 (Naa20) | AMPK-mTOR signaling pathway | Cell proliferation, autophagy | Jung et al. (2020) |
| - | PTEN signaling | Cell proliferation and angiogenesis | Zhang et al. (2020a) |
| CBP and SIRT1 | PTEN signaling and pro-apoptotic protein caspase-3 | Cell proliferation, migration, invasion, and apoptosis | Xue et al. (2020) |
| - | p38 MAPK signaling | Cell stemness and metastasis | Luk et al. (2020) |
| HDAC3 | TRAF6/c-Myc signaling | Cell proliferation | Wu et al. (2020) |
| HDAC1 | PTEN/Akt signaling | Cell proliferation, migration and invasion | Tian et al. (2017) |
| PCAF | STAT3 signaling | Cell proliferation | Zheng et al. (2016b) |
| HDAC11 | AMPK Signaling | Cell stemness | Bi et al. (2021) |
| P300/SIRT1 | YAP signaling | Cell proliferation, apoptosis | Wang et al. (2015) |