TABLE 4.

Expression and target genes of HATs/HDACs in HCC.

HATs/HDACs	Differential expression in HCC	Target genes	Biological processes/cellular functions	References
HDAC1	↑	E-cadherin	EMT	Hu et al. (2019)
		CCAAT/enhancer binding protein β (C/EBPβ)	EMT	Huo et al. (2021)
		hypoxia-inducible factor 1α (HIF-1α)	EMT	Yoo et al. (2008); Liu et al. (2013)
		FBP1	gluconeogenesis	Yang et al. (2017)
		P53	Apoptosis	Zhang et al. (2020b)
HDAC2	↑	E-cadherin	EMT	Hu et al. (2019)
		integrin αV subunit gene	cell migration	Cai et al. (2019)
HDAC3	-	E-cadherin	EMT	Hu et al. (2019)
		ANCR	HCC metastasis	Wen et al. (2020)
HDAC6	↓	HIF-1α and VEGFA	angiogenesis	Lv et al. (2016)
HDAC8	↓	PKM2	Glycolysis	Zhang et al. (2020c)
SIRT1	↑	hnRNP A1	Glycolysis	Yang et al. (2019)
		LC3	Autophagy	Li et al. (2016)
		P53	Apoptosis	Lee et al. (2012); Lin et al. (2019)
SIRT2	↑	protein kinase B	EMT	Chen et al. (2013)
SIRT5	↑	cytochrome c	mitochondrial apoptosis	Zhang et al. (2019)
SIRT5	↓	Vimentin	EMT	Guo et al. (2018)
SIRT6	↑	FOXO3a; Beclin-1	EMT	Han et al. (2019)
		hnRNP A1	Glycolysis	Yang et al. (2019)
		Ku70	Apoptosis	Tao et al. (2017)
SIRT7	↑	PGK1	cell proliferation	Hu et al. (2017)
		MEF2D	Immunity	Xiang et al. (2020)
P300	↑	HMGA2	HCC metastasis	Liang et al. (2021)
		DDK1	HCC metastasis	Niu et al. (2020)
		P53	glycogen metabolism	Chen et al. (2019); Di Leo et al. (2019)
		P53	apoptosis	Zhang et al. (2020b)
hMOF	↑	AXL;LGALS1	cell migration	Pote et al. (2020)
PCAF	↓	PGK1	cell proliferation	Hu et al. (2017)
		GLI1	apoptosis	Gai et al. (2015)