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. 2022 Aug 25;13:954106. doi: 10.3389/fphys.2022.954106

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Copyright © 2022 Man, An, Monchamp, Sekyonda, Kucukal, Federici, Wulftange, Goreke, Bode, Sheehan and Gurkan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Both ektacytometry and the OcclusionChip can effectively detect the abnormal RBC deformability in SCD. (A) At all the three shear stress levels (3, 16.87 and 30 Pa), the Elongation Index (EI) of RBCs from subjects with homozygous SCD (HbSS) is significantly lower than those from healthy donors (HbAA) by ektacytometry (p < 0.05, student’s t-test). (B) The Occlusion Index (OI) of RBCs from subjects with homozygous SCD (HbSS) is significantly greater than those from healthy donors (HbAA) by the OcclusionChip assay (p < 0.05, Mann-Whitney). Values shown are mean ± standard deviation (N = 4). * denotes a statistical significance between HbAA and HbSS (p < 0.05).