TABLE 1.
Subject hematological parameters for process validation. Values shown are mean ± standard deviation (range). N = 4 in each group.
| Clinical variables | OcclusionChip | Ektacytometry | Normal range |
|---|---|---|---|
| Mean ± SD (range) | Mean ± SD (range) | ||
| Age (years) | 44 ± 6 (38–51) | 34 ± 8 (22–41) | N/A |
| Hemoglobin (g/dl) | 8.2 ± 1.7 (6.4–9.9) | 8.4 ± 0.9 (7.6–9.6) | 12.0–18.0 |
| Red blood cell count (1012/L) | 3.4 ± 1.4 (2.0–4.8) | 2.5 ± 0.2 (2.2–2.8) | 4.2–6.1 |
| Hematocrit (%) | 25.7 ± 7.0 (19.1–31.9) | 24.9 ± 2.4 (21.8–27.6) | 36.0–50.0 |
| Absolute reticulocyte count (109/L) | 370 ± 175 (184–590) | 331 ± 228 (189–671) | 20–150 |
| Lactate dehydrogenase (U/L) | 420 ± 318 (134–745) | 298 ± 33 (256–336) | 140–280 |
| Ferritin (μg/L) | 1709 ± 2,484 (15–5,280) | 2,615 ± 2,206 (216–5,520) | 12–300 |
| White blood cell count (109/L) | 10.2 ± 2.6 (7.7–12.5) | 12.0 ± 4.1 (7.9–17.2) | 4.0–11.0 |
| Absolute neutrophil count (106/L) | 6,290 ± 2,705 (2,680–8,880) | 6,048 ± 2,145 (3,130–8,300) | 1,500–8,000 |
| Platelet count (109/L) | 400 ± 132 (268–546) | 475 ± 128 (326–637) | 150–400 |
| Hemoglobin S (%) | 51.5 ± 9.0 (41.3–62.4) | 61.7 ± 28.0 (20.5–79.9) | N/A |
| Hemoglobin A (%) | 35.4 ± 6.3 (27.9–41.4) | 21.1 ± 25.8 (1.9–57.1) | 99–100 |
| Hemoglobin F (%) | 1.9 ± 1.9 (0.5–4.6) | 7.9 ± 7.5 (1.1–16.5) | 0–0.9 |