FIGURE 1.

The timeline illustrates what the authors consider the most disruptive contribution in the p53 research over the last 40 years. Color coding shows seminal and breakthrough discoveries (gray), structural biology contribution (pink), therapeutic strategies (yellow), p53 gain-of-function examples (red), and p53-HOS research (green). We apologize to our colleagues in the p53 field whose work was not cited due to space limitations. References included in the timeline but not mentioned in the text: (Michalovitz et al., 1990; Farmer et al., 1992; Selivanova et al., 1997; Verhaegh et al., 1998; Foster et al., 1999; Stommel et al., 1999; Martinez et al., 2002; Yin et al., 2002; Lambert et al., 2009; Hu et al., 2010a; Adriaens et al., 2016; Kadosh et al., 2020; Maor-Nof et al., 2021).