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. 2022 Aug 25;13:949314. doi: 10.3389/fgene.2022.949314

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Copyright © 2022 Cai, Ji, Wu, Chen, Zheng, Chen, Zhang, Xie, Huang, Chen, Lin, Lin, Chen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential drug sensitivity analysis by IC50 and the immune checkpoint gene expression analysis between the high- and low-risk groups. (A–T) The boxplots for the drug sensitivity analysis of (A) ABT.888. (B) AP.24534. (C) ATRA. (D) AZD6244. (E) Bosutinib. (F) Etoposide. (G) Gefitinib. (H) GNF.2. (I) IPA.3. (J) KIN001.135. (K) Lenalidomide. (L) Methotrexate. (M) Nilotinib. (N) PAC.1. (O) PD.173074. (P) PF.4708671. (Q) Pyrimethamine. (R) Shikonin. (S) Temsirolimus. (T) VX.702. Top 20 significantly associations were displayed, as determined by the p-value. (U) Differential expression analysis of the immune checkpoint genes between the high-risk and low-risk groups. IC50, the half-maximal inhibitory concentration; *, p < 0.05; **, p < 0.01; ***, p < 0.001.