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. 2022 Aug 31;2022:8543720. doi: 10.1155/2022/8543720

Figure 4.

Figure 4

RNA sequencing was used to screen the differentially expressed lncRNAs in DSS-induced colitis mouse colon tissue. (a) Heatmap showing the differentially expressed lncRNAs between the colon tissues of the control, DSS+PBS, and DSS+IL-22 groups of mice. Red color is used to show the upregulated genes, and green color is used to show the downregulated genes. (b) KEGG pathway analysis showed the possible signaling pathway that may be involved in the differentially expressed lncRNA regulatory network. (c) qRT-PCR was performed to validate the identity of the top 5 lncRNAs, which were most differentially expressed in colon tissues between all groups of mice. lncRNA NONMMUG038140 (lncRNA-UCL) was selected as the target and to be used in further studies. Data are presented as mean ± SEM. ###P < 0.001; ##P < 0.01; #P < 0.05 using Student's t-test.