Table 1.
Characteristics of patients with LPA compared with lung ADC-NOS.
| Characteristics | LPA n = 4191 (%) | ADC-NOS n = 95004 (%) | P value |
|---|---|---|---|
| Age, years | |||
| 0–69 | 1994 (47.6) | 55203 (58.1) | <0.001 |
| 70–79 | 1438 (34.3) | 26630 (28.0) | |
| ≥80 | 759 (18.1) | 13171 (13.9) | |
| Sex | |||
| Male | 1591 (38.0) | 46856 (49.3) | <0.001 |
| Female | 2600 (62.0) | 48148 (50.7) | |
| Race | |||
| White | 3372 (80.5) | 74655 (78.6) | <0.001 |
| Black | 356 (8.5) | 11469 (12.1) | |
| Others | 463 (11.0) | 8880 (9.3) | |
| Marital status | |||
| Married | 2460 (58.7) | 52085 (54.8) | <0.001 |
| Single | 1731 (41.3) | 42919 (45.2) | |
| Education | |||
| High | 2065 (49.3) | 47790 (50.3) | 0.197 |
| Low | 2126 (50.7) | 47214 (49.7) | |
| Income | |||
| High | 2055 (49.0) | 48741 (51.3) | 0.004 |
| Low | 2136 (51.0) | 46263 (48.7) | |
| Laterality | |||
| Left | 1620 (38.7) | 36177 (38.1) | <0.001 |
| Right | 2447 (58.4) | 54374 (57.2) | |
| Unknown | 124 (3.0) | 4453 (4.7) | |
| Lobe | |||
| Upper | 2195 (52.4) | 51289 (54.0) | <0.001 |
| Middle | 199 (4.7) | 4317 (4.5) | |
| Lower | 1444 (34.5) | 24035 (25.3) | |
| Unknown | 353 (8.4) | 15363 (16.2) | |
| Tumor size | |||
| <3 cm | 2229 (53.2) | 31494 (33.2) | <0.001 |
| ≥3 and <5 cm | 915 (21.8) | 24387 (25.7) | |
| ≥5 cm | 530 (12.6) | 22377 (23.6) | |
| Unknown | 517 (12.3) | 16746 (17.6) | |
| Separate tumor nodules | |||
| Yes | 361 (8.6) | 15476 (16.3) | <0.001 |
| No | 1195 (28.5) | 40383 (42.5) | |
| Unknown | 2635 (62.9) | 39145 (41.2) | |
| Pleural invasion | |||
| Yes | 117 (2.8) | 5017 (5.3) | <0.001 |
| No | 714 (17.0) | 11117 (11.7) | |
| Unknown | 3360 (80.2) | 78870 (83.0) | |
| Grade | |||
| I | 1636 (39.0) | 6203 (6.5) | <0.001 |
| II | 1086 (25.9) | 20984 (22.1) | |
| III | 249 (5.9) | 27993 (29.5) | |
| IV | 7 (0.2) | 606 (0.6) | |
| Unknown | 1213 (28.9) | 39218 (41.3) | |
| Stage | |||
| I | 2261 (53.9) | 19370 (20.4) | <0.001 |
| II | 172 (4.1) | 4007 (4.2) | |
| III | 603 (14.4) | 20127 (21.2) | |
| IV | 1155 (27.6) | 51500 (54.2) | |
| Primary tumor surgery | |||
| Yes | 2646 (63.1) | 24886 (26.2) | <0.001 |
| No/unknown | 1545 (36.9) | 70118 (73.8) | |
| Metastatic tumor surgery | |||
| Yes | 74 (1.8) | 5499 (5.8) | <0.001 |
| No/unknown | 4117 (98.2) | 89505 (94.2) | |
| Radiotherapy | |||
| Yes | 639 (15.2) | 39072 (41.1) | <0.001 |
| No/unknown | 3552 (84.8) | 55932 (58.9) | |
| Chemotherapy | |||
| Yes | 1226 (29.3) | 46273 (48.7) | <0.001 |
| No/unknown | 2965 (70.7) | 48731 (51.3) | |
ADC: adenocarcinoma; LPA: lepidic adenocarcinoma; NOS: not otherwise specified.