Large and small chromosomes of Cladosporium fulvum Race 5 differ in gene content. (a) Overall gene density, i.e. counts per million base pairs, of specific categories of genes in each chromosome. Chromosome were grouped using a hierarchical clustering performed using the complete method based on the Euclidean distances. (b) Principal component analysis biplot grouping the chromosomes based on gene density. The mini-chromosome 14 appears far from the others, as this chromosome contains only hypothetical genes. Chromosomes 1 to 13 can be organized into two groups based on their size. One group contains chromosome 1 to chromosome 7 (the seven largest chromosomes) which, overall, have higher densities of genes encoding ATP-binding cassette (ABC) transporters and BUSCO genes. Chromosome 8 to chromosome 13 have, overall, higher densities of genes encoding key enzymes for secondary metabolism and major facilitator superfamily (MFS) transporters.