Table 2.

Pathway analysis for the 46 critical metabolites based on KEGG.

Pathway name	Total	Hits	p	−log(p)	Impact
Arginine and proline metabolism	38	4	0.015	1.8266	0.13566
Ascorbate and aldarate metabolism	8	2	0.016	1.7829	0
Phenylalanine metabolism	10	2	0.026	1.591	0.2619
Aminoacyl-tRNA biosynthesis	48	4	0.033	1.4862	0
Arginine biosynthesis	14	2	0.049	1.3134	0.30457
Glycine, serine, and threonine metabolism	33	3	0.051	1.2935	0.3387
Butanoate metabolism	15	2	0.055	1.2583	0.03175
Pentose and glucuronate interconversions	18	2	0.077	1.1158	0.29688
Pyrimidine metabolism	39	3	0.077	1.1154	0.09694
Phenylalanine, tyrosine, and tryptophan biosynthesis	4	1	0.099	1.0027	0
Pentose phosphate pathway	22	2	0.108	0.96468	0.04712