TABLE 2.
Intervention details of included RCTs.
| Study | Treatment in intervention group | Treatment in intervention group |
|---|---|---|
| Bao (2020) | Yiqi Huoxue Formula combined with SOX regimen chemotherapy. Formula composition: Acruginous turmeric, Chinese angelica, Finger citron, Villous amomum, Sanchi, Codonopsis, Astragalus | SOX regimen for 4 cycles: S-1 Capsules 40 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Cai et al. (2019) | Jianpi Yiqi Formula combined with XELOX regimen chemotherapy. Formula composition: Codonopsis, Poria, Largehead atractylodes, Perilla frutescens leaf, Coxi seed, Pinellia, Inula, Ruddle, Villous amomum, Liquorice | XELOX regimen for 3 cycles: Capetabine 1,000 mg/m2, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Chen et al. (2007) | TCM syndrome differentiation treatment combined with FOLFOX regimen chemotherapy | FOLFOX regimen chemotherapy: Oxaliplatin injection 130 mg/m2 intra venous drip on day 1; CF 200 mg intra venous drip on day 1–3; 5-Fu 400 mg/m2 on day 1, and a infusion (2,000 mg/m2) for 70 consecutive hours, one cycle for 21 days |
| Chi et al. (2010) | Yiqi Huoxue Formula combined with FOLFOX regimen chemotherapy. Formula composition: Astragalus, Pseudostellaria, Suberect spatholobus, Largehead atractylodes, Poria, Wolfberry, Ligustrum, Cuscuta, Red paeony, Coxi seed, Actinidia root | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1–2, and a 20-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Chu et al. (2017) | Zhangshi Yiwei Decoction combined with FOLFOX regimen chemotherapy. Formula composition: Largehead atractylodes, Poria, Codonopsis, Coptis, Tangerine peel, Thunberbg fritillary, Aucklandia, Pinellia, Villous amomum, Dandelion, Silktree bark, Bletilla, Liquorice | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 130 mg/m2 intra venous drip on day 1; CF 100 mg/m2 intra venous drip on day 1–5; 5-Fu 300 mg/m2 on day 1–5, one cycle for 21 days |
| Feng et al. (2021) | Xuezheng Decoction combined with XELOX regimen chemotherapy. Formula composition: Acruginous turmeric, Hedyotis diffusa, Smilax, Chinese angelica, Red paeony, Sparganii, Cassia twig, Frankincense, Myrrh | XELOX regimen for 2 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 85 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Feng (2017) | Gancao Xiexin Decoction combined with SOX regimen chemotherapy. Formula composition: Liquorice, Scutellaria, Coptis, Pinellia, Dried ginger, Ginseng, Red date | SOX regimen: S-1 Capsules 40–60 mg, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Gong (2020) | Wenyang Sanjie Decoction combined with SOX regimen chemotherapy. Formula composition: Astragalus, Yam, Chinese clematis, Coxi seed, Scutellaria barbata, White paeony, Ruddle, Largehead atractylodes, Psoralea, Cuscuta, Barley sprout, Dandelion, Wolfberry, Acruginous turmeric, Membrane of chickens gizzard, Inula, Pinellia, Gekko, Cassia twig, Tangerine peel, Dried ginger | SOX regimen: S-1 Capsules 40–60 mg, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Gu et al. (2019) | Jianwei Yiai Powder combined with FOLFOX regimen chemotherapy. Formula composition: Nightshade, Vietnamese sophora root, Scutellaria barbata, Hedyotis diffusa, Scolopendra, Pinellia, Arcae concha, Aucklandia, Poria, Suberect spatholobus, Codonopsis, Largehead atractylodes, Liquorice | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Guo (2014) | Wenyang Sanjie Decoction combined with SOX regimen chemotherapy. Formula composition: Codonopsis, Astragalus, Largehead atractylodes, Poria, Ligustrum, Pinellia, Hedyotis diffusa, Cremastra, Tangerine peel, Actinidia root, Membrane of chickens gizzard, Liquorice | SOX regimen: S-1 Capsules 40 mg, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Hu (2011) | Yiqi Huoxue Jiedu Formula combined with XELOX regimen chemotherapy. Formula composition: Astragalus, Codonopsis, Pseudostellaria, Largehead atractylodes, Poria, Wolfberry, Ligustrum Cuscuta, Suberect spatholobus, Red paeony, Acruginous turmeric, Paris polyphylla, Hedyotis diffusa, Actinidia root | XELOX regimen for 3 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 85 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Huang (2017) | Jianpi Yangwei Formula combined with FOLFOX4 regimen chemotherapy. Formula composition: Hedyotis chrysotricha, Smilax, Coxi seed, Yam, Codonopsis, Largehead atractylodes, Poria, Aucklandia, Chinese angelica, White paeony, Liquorice | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Huang (2014) | Jianpi Huayu Decoction combined with FOLFOX4 regimen chemotherapy. Formula composition: Codonopsis, Largehead atractylodes, Dandelion, Perilla frutescens stem, Nardostachys, Snakegourd seed, Pinellia, Gekko, Acruginous turmeric, Crataegi, Rhei, Magnolia bark, Membrane of chickens gizzard | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Jiang et al. (2021) | Jiedu Sanjie Formula combined with SOX regimen chemotherapy. Formula composition: Dandelion, Prunella, Honeysuckle, Forsythia, Chinese angelica, Figwort, Isatis, Stiff silkworm, Myrrh, Scorpion, Gleditsia sinensis | SOX regimen: S-1 Capsules 40–60 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Jiao (2019) | Modified Xuezheng Decoction combined with FOLFOX4 regimen chemotherapy. Formula composition: Sparganii, Acruginous turmeric, Hedyotis diffusa, Smilax, Chinese angelica, Red paeony, Frankincense, Myrrh, Cassia twig | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Li (2016) | Fuzheng Kangai Formula combined with FOLFOX4 regimen chemotherapy. Formula composition: Largehead atractylodes, Morinda, Wolfberry, Drynaria Rehmannia glutinosa, Epimedium, Cornus, Ginseng, Eucommia, Psoralea, Cassia bark, Chinese angelica, Curculigo | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Li Y. et al. (2020) | Shunqi Yiwei Decoction combined with SOX regimen chemotherapy. Formula composition: Bupleurum, Aurantii fructus, White paeony, Liquorice, Poria, Atractylodis, Codonopsis | SOX regimen: S-1 Capsules 40 mg, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Liu et al. (2015) | Jianpi Xiaozheng Formula combined with SOX regimen chemotherapy. Formula composition: Astragalus, Smilax, Hedyotis chrysotricha, Coxi seed, Codonopsis, Poria, Yam, Sparganii, Acruginous turmeric, Largehead atractylodes, Aucklandia, Tangerine peel, Chinese angelica, White paeony | SOX regimen: S-1 Capsules 40–60 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Liu et al. (2019) | Jianpi Huayu Formula combined with FOLFOX4 regimen chemotherapy. Formula composition: Largehead atractylodes, Dandelion, Perilla frutescens stem, Nardostachys, Snakegourd seed, Pinellia, Gekko, Acruginous turmeric, Crataegi, Rhei, Magnolia bark, Membrane of chickens gizzard | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1–2; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Long (2021) | Yiqi Fuyuan Formula combined with mFOLFOX6 regimen chemotherapy. Formula composition: Astragalus, Codonopsis, Largehead atractylodes, Aucklandia, Tangerine peel, Poria, Chinese angelica, Spine date seed, Yam, Raw ginger, Lotus seed, Liquorice | mFOLFOX6 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 400 mg/m2 intra venous drip on day 1; 5-Fu 400 mg/m2 on day 1, and a infusion (2,400 mg/m2) for 46 consecutive hours, one cycle for 21 days |
| Qin (2012) | Modified Buzhong Yiqi Decoction combined with SOX regimen chemotherapy. Formula composition: Astragalus, Codonopsis, Largehead atractylodes, Liquorice, Chinese angelica, Sichuan lovase, Tangerine peel, Acruginous turmeric, Hedyotis diffusa, Coxi seed | SOX regimen: S-1 Capsules 80 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Sun et al. (2020) | Fuzheng Kangai Formula combined with FOLFOX6 regimen chemotherapy. Formula composition: Codonopsis, Largehead atractylodes, Bupleurum, White paeony, Poria, Tangerine peel, Pinellia, Sichuan lovase, Aurantii fructus, Ligustrum, Ganoderma, Barley sprout, Millet sprout, Paris polyphylla, Scutellaria barbata, Hedyotis diffusa, Liquorice | FOLFOX6 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 400 mg/m2 intra venous drip on day 1; 5-Fu 400 mg/m2 on day 1, and a infusion (2,400 mg/m2) for 46 consecutive hours, one cycle for 21 days |
| Wang Y. et al. (2018) | Guishao Liujunzi Decoction combined with SOX regimen chemotherapy. Formula composition: Chinese angelica, White paeony, Codonopsis, Poria, Largehead atractylodes, Yam, Coxi seed, Tangerine peel, Pinellia, Hedyotis diffusa, Scutellaria barbata, Sparganii, Acruginous turmeric, Liquorice | SOX regimen: S-1 Capsules 50 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Xie (2019) | Wendan Decoction combined with XELOX regimen chemotherapy. Formula composition: Pinellia, Bambusae caulis, Aurantii fructus Immaturus, Tangerine peel, Poria, Liquorice, Raw ginger, Red date | XELOX regimen for 3 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 85 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Yang et al. (2018) | Shenyu Yangwei Decoction combined with XELOX regimen chemotherapy. Formula composition: Ginseng, Cornus, Dendrobium, Salviae | XELOX regimen for 2 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Yu et al. (2019) | Modified Shengyang Yiwei Decoction combined with XELOX regimen chemotherapy. Formula composition: Ginseng, Cornus, Dendrobium, Salviae | XELOX regimen for 2 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Yuan (2011) | Modified Shengyang Yiwei Decoction combined with XELOX regimen chemotherapy. Formula composition: Codonopsis, Largehead atractylodes, Poria, Coxi seed, Pinellia, Tangerine peel, Agaric Yam, Millet sprout, Barley sprout, Poria with hostwood, Loquat leaf, Liquorice | XELOX regimen for 2 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 2 h on day 1, one cycle for 21 days |
| Yuan (2018) | Yiqi Jiedu Formula combined with SOX regimen chemotherapy. Formula composition: Ginseng, Gekko, Paris polyphylla, Pinellia, Tangerine peel, Magnolia bark, Liquorice | SOX regimen: S-1 Capsules 40 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Zhai (2019) | Huayu Jiedu Formula combined with SOX regimen chemotherapy. Formula composition: Scorpion, Gekko, Sanchi, Nitroum, Scutellaria barbata, Membrane of chickens gizzard | SOX regimen: S-1 Capsules 40–60 mg, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 3 h on day 1, one cycle for 21 days |
| Zhang (2021a) | Modified Shiquan Dabu Decoction combined with XELOX regimen chemotherapy. Formula composition: Astragalus, Coxi seed, Largehead atractylodes, Poria, Chinese angelica, Pinellia, White paeony, Rehmannia glutinosa, Sparganii, Acruginous turmeric, Sichuan lovase, Ginseng, Cassia bark, Villous amomum, Liquorice | XELOX regimen: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 2 h on day 1, one cycle for 21 days |
| Zhang (2021a) | TCM syndrome differentiation treatment combined with XELOX regimen chemotherapy | XELOX regimen for 3 cycles: Capetabine 1,000 mg/m2, twice daily, once after breakfast and dinner respectively, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for 2 h on day 1, one cycle for 21 days |
| Zhang (2021b) | Shugan Yangwei Decoction combined with SOX regimen chemotherapy. Formula composition: Bupleurum, White paeony, Scutellaria, Aurantii fructus Immaturus, Coptis, Dried ginger, Pinellia, Aucklandia, Rhei, Salviae, Toosendan Corydalis Codonopsis, Katsumada galangal, Liquorice | SOX regimen: S-1 Capsules 40∼60 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Zhang et al. (2020) | Shengyang Yiwei Decoction combined with SOX regimen chemotherapy. Formula composition: Astragalus, Pinellia, Ginseng, Liquorice, Angelicae tuhuo, Divaricate saposhniovia, White paeony, Notopterygium, Tangerine peel, Poria, Bupleurum, Alisma orientale, Largehead atractylodes, Coptis | SOX regimen: S-1 Capsules 60 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Zhang (2019) | Erteng Sanjie Capsule combined with SOX regimen chemotherapy. Formula composition: Pseudostellaria, Largehead atractylodes, Coxi seed, Pinellia, Tangerine peel, Villous amomum, Gekko, Sargentgloryvine Smilax, Amur grape vines, Actinidia root, Prunella, Ostreae concha, Acruginous turmeric, Areca, Liquorice | SOX regimen: S-1 Capsules 40∼60 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Zhao (2011) | Kun Shen Granule combined with FOLFOX regimen chemotherapy. Formula composition: Laminaria, Actinidia root, Agrimony, Ginseng | FOLFOX regimen chemotherapy for 2 cycles: Oxaliplatin injection 200 mg intra venous drip on day 1; CF 300 mg intra venous drip on day 1–5; 5-Fu 750 mg on day 1–5, one cycle for 21 days |
| Zhao (2016) | Jianpi Huayu Formula combined with SOX regimen chemotherapy. Formula composition: Pseudostellaria, Largehead atractylodes, Paris polyphylla, Salviae, Scutellaria barbata, Salvia chinensis, Hedyotis diffusa, Poria, Nightshade, Dendrobium, Yam | SOX regimen: S-1 Capsules 60∼80 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 65 mg/m2 intra venous drip for 3 h on day 1 and day 8, one cycle for 21 days |
| Zhao (2021) | Wenyang Jianpi Decoction combined with SOX regimen chemotherapy. Formula composition: Pseudostellaria, Hedyotis diffusa, Largehead atractylodes, Acruginous turmeric, Nightshade, Millet sprout, Barley sprout, Pinellia, Poria, Tangerine peel, Aurantii fructus, Cassia twig, Dried ginger, Liquorice | SOX regimen: S-1 Capsules 40 mg, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip on day 1, one cycle for 21 days |
| Zhong et al. (2021) | Jianpi Fuzheng Xiaoliu Formula combined with XELOX regimen chemotherapy. Formula composition: Pseudostellaria, Coxi seed, Largehead atractylodes, Hedyotis diffusa, Smilax, Scutellaria barbata, Sparganii, Acruginous turmeric, Poria, Yam, Chinese angelica, Crataegi, Liquorice, Membrane of chickens gizzard | XELOX regimen for 4 cycles: Capetabine 1,000 mg/m2, twice daily, taking it for 14 days, stopping for 7 days; Oxaliplatin injection 130 mg/m2 intra venous drip for on day 1, one cycle for 21 days |
| Zhong et al. (2019) | Modified Shenling Baizhu Decoction combined with FOLFOX4 regimen chemotherapy. Formula composition: Tangerine peel, Cimicifuga, Bupleurum, Platycodon, Liquorice, Lotus seed, Villous amomum, Chinese angelica, Largehead atractylodes, Dolichos, Poria, Yam, Codonopsis, Astragalus, Coxi seed | FOLFOX4 regimen chemotherapy: Oxaliplatin injection 85 mg/m2 intra venous drip on day 1; CF 200 mg/m2 intra venous drip on day 1; 5-Fu 400 mg/m2 on day 1, and a 22-h infusion (600 mg/m2/d) for 2 consecutive days, one cycle for 21 days |
| Zhu (2011) | Jianpi Yiqi Decoction combined with FOLFOX regimen chemotherapy. Formula composition: Astragalus, Crataegi, Scorch-fried medicated leaven, Barley sprout, Adenophorae, Glehnia, Solomonseal, Tangerine peel, Pinellia, Finger citron, Magnolia bark, Membrane of chickens gizzard, Villous amomum, Whitefruit amomim, Liquorice | FOLFOX regimen chemotherapy for 2 cycles: Oxaliplatin injection 135 mg/m2 intra venous drip on day 1; CF 100 mg/m2 intra venous drip on day 1–5; 5-Fu 500 mg/m2 on day 1–5, one cycle for 21 days |